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姓名:刘思金 [博士生导师] 性别:男职称: 研究员 电话:E-mail:sjliu@rcees.ac.cn组别:环境污染与健康效应研究组 研究方向:环境医学与环境毒理学

简历:

        2004年6月毕业于中国科学院遗传与发育生物学研究所,获博士学位。2004年7月至2008年1月,先后在美国麻省理工学院(MIT)和美国哈佛大学医学院附属儿童医院完成博士后的学习和深造。2008年1月至2009年8月,在美国塔夫斯大学医学院任讲师。2009年,入选中科院“百人计划”,进入中国科学院生态环境研究中心工作。     

承担科研项目:

  1.  国家自然科学基金面上项目:纳米银的胚胎发育毒性机理研究,项目批准号:21177151,2012.1-2015.12。
  2. 国家自然科学基金面上项目:多氯联苯(PCBs)暴露对乳腺癌肿瘤转移的   影响及相关分子机制的研究,项目批准号:21077128,2011.1-2013.12。
  3. 中科院知识创新工程重要方向项目:典型有机磷农药和重金属的联合毒性效应与作用机理,项目批准号:KZCX2-EW-404,2011.1-2013.12。
  4. 中国科学院“百人计划”项目:持久性有机污染物的分子毒理学研究,  2010.1-2014.12。
  5. 国家自然科学基金青年项目:纳米银对巨噬细胞毒性的机理研究。项目批准号:21207152,2013.1-2015.12。

获奖及荣誉:

        作为主申请人曾两次获美国Cooley's贫血基金学会的资助和美国血液学会、美国骨骼与矿物质研究学会的奖励。曾先后获得第九届PTS青年科学家奖(The 9th International Symposium on Persistent Toxic Substances)等。作为POPs研究集体的主要完成者,获中科院2013年度杰出科技成就奖等。2015年获高登学术会议(Gordon conference)Nature Travel Award(由 Nature 杂志授予的奖励)。





代表论著:

  1. Chen, Y., Xu, M., Zhang, J., Ma, J., Gao, M., Zhang, Z.*, Xu, Y., Liu, S.* (2016) Genome-wide DNA methylation variations upon engineered nanomaterials and their implications in nanosafety assessment. Adv Mater. In press.
  2. Xu, M., Zhu, J., Wang, F., Xiong, Y., Wu, Y., Wang, Q., Weng, J.*, Zhang, Z.*, Chen, W., Liu, S.* (2016) Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation. ACS Nano. 10:3267-81.
  3. Wang, S., Shang, L., Li, L., Yu, Y., Chi, C., Wang, K., Zhang, J., Shi, R., Shen, H., Waterhouse, GI., Liu, S.*, Tian, J., Zhang, T.*, Liu, H.*. (2016) Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy. Adv Mater. 28:8379-87.
  4. Ma, J., Liu, R., Wang, X., Liu, Q., Chen, Y., Valle, RP., Zuo, YY., Xia, T.*, Liu, S.* (2015) Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals. ACS Nano. 9:10498-515.
  5. Qian, Y., Zhang, J., Hu, Q., Xu, M., Chen, Y., Hu, G., Zhao, M.*, Liu, S.* (2015) Silver nanoparticle-induced hemoglobin decrease involves alteration of histone 3 methylation status. Biomaterials. 70:12-22.
  6. Chen, Y., Zhang, Z., Yang, K., Du, J., Xu, Y.*, Liu, S.* (2015). Myeloid zinc finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress. Oncogene. 34:3839-47.
  7. Chen, Y., Wang, Z., Xu, M., Wang, X., Liu, R., Liu, Q., Zhang, Z., Xia, T., Zhao, J., Jiang, G., Xu, Y., Liu, S.* (2014). Nanosilver incurs an adaptive shunt of energy metabolism mode to glycolysis in tumor and nontumor cells. ACS Nano. 8:5813-25.
  8. Zhang, C., Zhang, S., Zhang, Z., He, J., Xu, Y.*, Liu, S.* (2014) ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc. Oncogene. 33:5582-91.
  9. Qu, G., Liu, S.*, Zhang, S., Wang, L., Wang,X., Sun, B., Yin, N., Gao, X., Xia,T., Chen, J.J.,  Jiang,G. (2013). Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages. ACS Nano. 7:5732-45.
  10. Wang, Z., Liu, S.*, Ma, J., Qu, G., Wang, X., Yu, S., He, J., Liu, J., Xia, T., Jiang, G. (2013). Silver Nanoparticles Induced RNA Polymerase-Silver Binding and RNA Transcription Inhibition in Erythroid Progenitor Cells. ACS Nano. 7: 4171-86.
  11. Qu, G., Zhang, C., Yuan, L., He, J., Wang, Z., Wang, L., Liu, S.*, and Jiang, G. (2012). Quantum Dots Impair Macrophagic Morphology and the Ability of Phagocytosis by Inhibiting the Rho-Associated Kinase Signaling. Nanoscale. 4: 2239-44.
  12. Suragani, R.N., Zachariah, R.S., Velazquez, J.G., Liu, S., Sun, C.W., Townes, T.M., and Chen, J.J. (2012) Heme-regulated eIF2alpha kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. Blood. 119:5276-84.
  13. Liu, S., Goldstein, R.H., Scepansky, E.M., and Rosenblatt, M. (2009). Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone. Cancer Res. 69: 8742-51.
  14. Liu, S., Suragani, R., Wang, F., Han, A., Zhao, W., Andrews, N.C., and Chen, J.J. (2007). The Function of Heme-Regulated eIF2-alpha Kinase in Murine Iron Homeostasis and Macrophage Maturation. J Clin Invest. 117: 3296-305.