研究队伍
![](http://former.rcees.ac.cn/uploadfile/2016/1111/20161111015107461.jpg)
简历:
2004年6月毕业于中国科学院遗传与发育生物学研究所,获博士学位。2004年7月至2008年1月,先后在美国麻省理工学院(MIT)和美国哈佛大学医学院附属儿童医院完成博士后的学习和深造。2008年1月至2009年8月,在美国塔夫斯大学医学院任讲师。2009年,入选中科院“百人计划”,进入中国科学院生态环境研究中心工作。
承担科研项目:
- 国家自然科学基金面上项目:纳米银的胚胎发育毒性机理研究,项目批准号:21177151,2012.1-2015.12。
- 国家自然科学基金面上项目:多氯联苯(PCBs)暴露对乳腺癌肿瘤转移的 影响及相关分子机制的研究,项目批准号:21077128,2011.1-2013.12。
- 中科院知识创新工程重要方向项目:典型有机磷农药和重金属的联合毒性效应与作用机理,项目批准号:KZCX2-EW-404,2011.1-2013.12。
- 中国科学院“百人计划”项目:持久性有机污染物的分子毒理学研究, 2010.1-2014.12。
- 国家自然科学基金青年项目:纳米银对巨噬细胞毒性的机理研究。项目批准号:21207152,2013.1-2015.12。
获奖及荣誉:
作为主申请人曾两次获美国Cooley's贫血基金学会的资助和美国血液学会、美国骨骼与矿物质研究学会的奖励。曾先后获得第九届PTS青年科学家奖(The 9th International Symposium on Persistent Toxic Substances)等。作为POPs研究集体的主要完成者,获中科院2013年度杰出科技成就奖等。2015年获高登学术会议(Gordon conference)Nature Travel Award(由 Nature 杂志授予的奖励)。
代表论著:
- Chen, Y., Xu, M., Zhang, J., Ma, J., Gao, M., Zhang, Z.*, Xu, Y., Liu, S.* (2016) Genome-wide DNA methylation variations upon engineered nanomaterials and their implications in nanosafety assessment. Adv Mater. In press.
- Xu, M., Zhu, J., Wang, F., Xiong, Y., Wu, Y., Wang, Q., Weng, J.*, Zhang, Z.*, Chen, W., Liu, S.* (2016) Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation. ACS Nano. 10:3267-81.
- Wang, S., Shang, L., Li, L., Yu, Y., Chi, C., Wang, K., Zhang, J., Shi, R., Shen, H., Waterhouse, GI., Liu, S.*, Tian, J., Zhang, T.*, Liu, H.*. (2016) Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy. Adv Mater. 28:8379-87.
- Ma, J., Liu, R., Wang, X., Liu, Q., Chen, Y., Valle, RP., Zuo, YY., Xia, T.*, Liu, S.* (2015) Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals. ACS Nano. 9:10498-515.
- Qian, Y., Zhang, J., Hu, Q., Xu, M., Chen, Y., Hu, G., Zhao, M.*, Liu, S.* (2015) Silver nanoparticle-induced hemoglobin decrease involves alteration of histone 3 methylation status. Biomaterials. 70:12-22.
- Chen, Y., Zhang, Z., Yang, K., Du, J., Xu, Y.*, Liu, S.* (2015). Myeloid zinc finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress. Oncogene. 34:3839-47.
- Chen, Y., Wang, Z., Xu, M., Wang, X., Liu, R., Liu, Q., Zhang, Z., Xia, T., Zhao, J., Jiang, G., Xu, Y., Liu, S.* (2014). Nanosilver incurs an adaptive shunt of energy metabolism mode to glycolysis in tumor and nontumor cells. ACS Nano. 8:5813-25.
- Zhang, C., Zhang, S., Zhang, Z., He, J., Xu, Y.*, Liu, S.* (2014) ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc. Oncogene. 33:5582-91.
- Qu, G., Liu, S.*, Zhang, S., Wang, L., Wang,X., Sun, B., Yin, N., Gao, X., Xia,T., Chen, J.J., Jiang,G. (2013). Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages. ACS Nano. 7:5732-45.
- Wang, Z., Liu, S.*, Ma, J., Qu, G., Wang, X., Yu, S., He, J., Liu, J., Xia, T., Jiang, G. (2013). Silver Nanoparticles Induced RNA Polymerase-Silver Binding and RNA Transcription Inhibition in Erythroid Progenitor Cells. ACS Nano. 7: 4171-86.
- Qu, G., Zhang, C., Yuan, L., He, J., Wang, Z., Wang, L., Liu, S.*, and Jiang, G. (2012). Quantum Dots Impair Macrophagic Morphology and the Ability of Phagocytosis by Inhibiting the Rho-Associated Kinase Signaling. Nanoscale. 4: 2239-44.
- Suragani, R.N., Zachariah, R.S., Velazquez, J.G., Liu, S., Sun, C.W., Townes, T.M., and Chen, J.J. (2012) Heme-regulated eIF2alpha kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. Blood. 119:5276-84.
- Liu, S., Goldstein, R.H., Scepansky, E.M., and Rosenblatt, M. (2009). Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone. Cancer Res. 69: 8742-51.
- Liu, S., Suragani, R., Wang, F., Han, A., Zhao, W., Andrews, N.C., and Chen, J.J. (2007). The Function of Heme-Regulated eIF2-alpha Kinase in Murine Iron Homeostasis and Macrophage Maturation. J Clin Invest. 117: 3296-305.