CHINESE
08-21-2019
Position:Home > Research group > Introduction > Environmental Pollution and Health Impact

  • Environmental Pollution and Health Impact

    Introduction

    The Environmental Pollution and Health Impact research group focuses on two cutting-edge research topics:

    a) The mechanisms responsible for the environmental pollutant-induced oncogenic effects. To explore biological mechanisms (e.g. oxidative stress pathway, iron-related pathway, etc.) responsible for development, progression and metastasis of cancers upon exposure to persistent organic pollutants (POPs) and heavy metals.

    b) Nanosafety and nanoimpact. To elaborate the bioavailability, toxic effects and interspecies transformation of nanomaterials under environmental exposure and to reveal the mechanisms controlling their toxicities. To define the structure-activity relationship for the environmental biological effects of nanomaterials. To develop risk evaluation models for na
                   


    Selected publications

    1. Zhu, J., Xu, M.,* Gao, M., Zhang, Z., Xu, Y., Xia, Y., Liu, S.* (2017) Graphene Oxide-Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents. ACS Nano. 2017, DOI: 10.1021/acsnano.6b07311. 
    2. Ma, J., Li, R., Liu, Y., Qu, G., Liu, J., Guo, W., Song, H., Li, X., Liu, Y., Xia, T., Yan, B., Liu, S.* (2017) Carbon nanotubes disrupt iron homeostasis and induce anemia of inflammation through inflammatory pathway as a secondary effect distant to their portal-of-entry. Small. 2017. doi: 10.1002/smll.201603830. 
    3. Ma, J., Li, R., Qu, G., Liu, H., Yan, B., Xia, T., Liu, Y., Liu, S.* (2016) Carbon nanotubes stimulate synovial inflammation by inducing systemic pro-inflammatory cytokines. Nanoscale. 8:18070-18086.
    4. Chen, Y., Wu, Y., Sun, B., Liu, S.,* Liu, H.* (2017) Two-dimensional nanomaterials for cancer nanotheranostics. Small. 2017. doi: 10.1002/smll.201603446. 
    5. Chen, Y., Xu, M., Zhang, J., Ma, J., Gao, M., Zhang, Z.*, Xu, Y., Liu, S.* (2016) Genome-wide DNA methylation variations upon engineered nanomaterials and their implications in nanosafety assessment. Adv Mater. 29(6): 1604580. 
    6. Xu, M., Zhu, J., Wang, F., Xiong, Y., Wu, Y., Wang, Q., Weng, J.*, Zhang, Z.*, Chen, W., Liu, S.* (2016) Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation. ACS Nano. 10:3267-81.
    7. Wang, S., Shang, L., Li, L., Yu, Y., Chi, C., Wang, K., Zhang, J., Shi, R., Shen, H., Waterhouse, GI., Liu, S.*, Tian, J., Zhang, T.*, Liu, H.*. (2016) Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy. Adv Mater. 28:8379-87.
    8. Ma, J., Liu, R., Wang, X., Liu, Q., Chen, Y., Valle, RP., Zuo, YY., Xia, T.*, Liu, S.* (2015) Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals. ACS Nano. 9:10498-515.
    9. Qian, Y., Zhang, J., Hu, Q., Xu, M., Chen, Y., Hu, G., Zhao, M.*, Liu, S.* (2015) Silver nanoparticle-induced hemoglobin decrease involves alteration of histone 3 methylation status. Biomaterials. 70:12-22.
    10. Chen, Y., Zhang, Z., Yang, K., Du, J., Xu, Y.*, Liu, S.* (2015). Myeloid zinc finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress. Oncogene. 34:3839-47.
    11. Chen, Y., Wang, Z., Xu, M., Wang, X., Liu, R., Liu, Q., Zhang, Z., Xia, T., Zhao, J., Jiang, G., Xu, Y., Liu, S.* (2014). Nanosilver incurs an adaptive shunt of energy metabolism mode to glycolysis in tumor and nontumor cells. ACS Nano. 8:5813-25.
    12. Zhang, C., Zhang, S., Zhang, Z., He, J., Xu, Y.*, Liu, S.* (2014) ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc. Oncogene. 33:5582-91.
    13. Qu, G., Liu, S.*, Zhang, S., Wang, L., Wang,X., Sun, B., Yin, N., Gao, X., Xia,T., Chen, J.J., Jiang, G. (2013). Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages. ACS Nano. 7:5732-45.
    14. Wang, Z., Liu, S.*, Ma, J., Qu, G., Wang, X., Yu, S., He, J., Liu, J., Xia, T., Jiang, G. (2013). Silver Nanoparticles Induced RNA Polymerase-Silver Binding and RNA Transcription Inhibition in Erythroid Progenitor Cells. ACS Nano. 7: 4171-86.
    15. Qu, G., Zhang, C., Yuan, L., He, J., Wang, Z., Wang, L., Liu, S.*, and Jiang, G. (2012). Quantum Dots Impair Macrophagic Morphology and the Ability of Phagocytosis by Inhibiting the Rho-Associated Kinase Signaling. Nanoscale. 4: 2239-44.
    16. Suragani, R.N., Zachariah, R.S., Velazquez, J.G., Liu, S., Sun, C.W., Townes, T.M., and Chen, J.J.* (2012) Heme-regulated eIF2alpha kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. Blood. 119:5276-84.
    17. Liu, S., Goldstein, R.H., Scepansky, E.M., and Rosenblatt, M.* (2009). Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone. Cancer Res. 69: 8742-51.
    18. Liu, S., Suragani, R., Wang, F., Han, A., Zhao, W., Andrews, N.C., and Chen, J.J.* (2007). The Function of Heme-Regulated eIF2-alpha Kinase in Murine Iron Homeostasis and Macrophage Maturation. J Clin Invest. 117: 3296-305.
     

    Supported Projects

    1. Ma, J., Li, R., Qu, G., Liu, H., Yan, B., Xia, T., Liu, Y., Liu, S.* (2016) Carbon nanotubes stimulate synovial inflammation by inducing systemic pro-inflammatory cytokines. Nanoscale. 8:18070-18086.
    2. Chen, Y., Xu, M., Zhang, J., Ma, J., Gao, M., Zhang, Z.*, Xu, Y., Liu, S.* (2016) Genome-wide DNA methylation variations upon engineered nanomaterials and their implications in nanosafety assessment. Adv Mater. doi: 10.1002/adma.201604580. [Epub ahead of print]
    3. Chen, Y., Wu, Y., Sun, B., Liu, S.,* Liu, H.* (2016) Two-dimensional nanomaterials for cancer nanotheranostics. Small. In press. 
    4. Xu, M., Zhu, J., Wang, F., Xiong, Y., Wu, Y., Wang, Q., Weng, J.*, Zhang, Z.*, Chen, W., Liu, S.* (2016) Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation. ACS Nano. 10:3267-81.
    5. Wang, S., Shang, L., Li, L., Yu, Y., Chi, C., Wang, K., Zhang, J., Shi, R., Shen, H., Waterhouse, GI., Liu, S.*, Tian, J., Zhang, T.*, Liu, H.*. (2016) Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy. Adv Mater. 28:8379-87.
    6. Ma, J., Liu, R., Wang, X., Liu, Q., Chen, Y., Valle, RP., Zuo, YY., Xia, T.*, Liu, S.* (2015) Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals. ACS Nano. 9:10498-515.
    7. Qian, Y., Zhang, J., Hu, Q., Xu, M., Chen, Y., Hu, G., Zhao, M.*, Liu, S.* (2015) Silver nanoparticle-induced hemoglobin decrease involves alteration of histone 3 methylation status. Biomaterials. 70:12-22.
    8. Chen, Y., Zhang, Z., Yang, K., Du, J., Xu, Y.*, Liu, S.* (2015). Myeloid zinc finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress. Oncogene. 34:3839-47.
    9. Chen, Y., Wang, Z., Xu, M., Wang, X., Liu, R., Liu, Q., Zhang, Z., Xia, T., Zhao, J., Jiang, G., Xu, Y., Liu, S.* (2014). Nanosilver incurs an adaptive shunt of energy metabolism mode to glycolysis in tumor and nontumor cells. ACS Nano. 8:5813-25.
    10. Zhang, C., Zhang, S., Zhang, Z., He, J., Xu, Y.*, Liu, S.* (2014) ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc. Oncogene. 33:5582-91.
    11. Qu, G., Liu, S.*, Zhang, S., Wang, L., Wang,X., Sun, B., Yin, N., Gao, X., Xia,T., Chen, J.J., Jiang, G. (2013). Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages. ACS Nano. 7:5732-45.
    12. Wang, Z., Liu, S.*, Ma, J., Qu, G., Wang, X., Yu, S., He, J., Liu, J., Xia, T., Jiang, G. (2013). Silver Nanoparticles Induced RNA Polymerase-Silver Binding and RNA Transcription Inhibition in Erythroid Progenitor Cells. ACS Nano. 7: 4171-86.
    13. Qu, G., Zhang, C., Yuan, L., He, J., Wang, Z., Wang, L., Liu, S.*, and Jiang, G. (2012). Quantum Dots Impair Macrophagic Morphology and the Ability of Phagocytosis by Inhibiting the Rho-Associated Kinase Signaling. Nanoscale. 4: 2239-44.
    14. Suragani, R.N., Zachariah, R.S., Velazquez, J.G., Liu, S., Sun, C.W., Townes, T.M., and Chen, J.J.* (2012) Heme-regulated eIF2alpha kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. Blood. 119:5276-84.
    15. Liu, S., Goldstein, R.H., Scepansky, E.M., and Rosenblatt, M.* (2009). Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone. Cancer Res. 69: 8742-51.
    16. Liu, S., Suragani, R., Wang, F., Han, A., Zhao, W., Andrews, N.C., and Chen, J.J.* (2007). The Function of Heme-Regulated eIF2-alpha Kinase in Murine Iron Homeostasis and Macrophage Maturation. J Clin Invest. 117: 3296-305.

    Awards

    1. 2015, the China Youth Science and Technology Award.

    2. 2015, the Chinese Academy of Sciences Yong Scientist Award.

    3. 2014, the “Excellent” Award for CAS Hundreds Talents Program.