CHINESE
08-21-2019
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  • Environmental chemicobiology research group

    Introduction

    Environmental chemicobiology research group focuses on: 1) Carbohydrate-based molecular design and synthesis: towards drug development, as well as fluorescent sensors preparation applicable to environment and life sciences. 2) Fate and toxicity of PPCPs in chlorination disinfection. 3) Interaction mechanism of POPs and bio-molecules in terms of glucose and lipids metabolism, aiming to pollutants exposure and the epidemics of metabolic syndromes.

    Selected publications

    1. Liping Li, Dongbin Wei, Guohua Wei, Yuguo Du, Oxidation of cefazolin by potassium permanganate: Transformation products and plausible pathways Chemosphere. 2016, 149, 279-285.
    2. Wei Liu, Dongbin Wei, Qi Liu, Yuguo Du, Transformation pathways and acute toxicity variation of 4-hydroxyl benzophenone in chlorination disinfection process. Chemosphere. 2016, 154, 491-498.
    3. Jingjing Bi, Jing Wang, Kai Zhou, Yuancheng Wang, Min Fang, and Yuguo Du,  Synthesis and Biological Activities of 5-Thio--GalCers, ACS Med. Chem. Lett, 2015, 6, 476-480.
    4. Xue Sun, Yi Liu, Jun Liu, Guofeng Gu, Yuguo Du, Synthesis and structural reconfirmation of bacillamide B, Org. Biomol. Chem., 2015, 13, 4271-4277.
    5. Yuan Li, Dongbin Wei, Yuguo Du, Oxidative transformation of levofloxacin by δ-MnO2: Products, pathways and toxicity assessment. Chemosphere. 2015, 119, 282-288.
    6. Jinshan Li, Chuanfang Zhao, Jun Liu, Yuguo Du,Total synthesis of proposed cephalosporolides H and I, Tetrahedron, 2015,71,3885-3889
    7. Qiuli Shan, Fengchen Huang, Wang Jing, Yuguo Du, Effects of co-exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated biphenyls on nonalcoholic fatty liver disease in mice, Environmental Toxicology, 2015, 30,1364-1374.
    8. Linlin Wang, Xing Zhang, Jun Liu, Yuguo Du, Total synthesis of (-)-petrosiol E, Tetrahedron, 2014, 70, 8231-8235.
    9. Yangguang Gao, Qiuli Shan, Jun Liu, Linlin Wang, Yuguo Du, The first convergent total synthesis of penarolide sulfate A2, a novel -glucosidase inhibitor, Org. Biomol. Chem., 2014, 12, 2071-2079.
    10. Yi Liu, Xue Sun, Xing Zhang, Jun Liu, Yuguo Du, Concise Synthesis of 2,4-disubstituted Thiazoles from β-Azdo Disulfides and Carboxylic Acids or Anhydrides: Asymmetric Synthesis of cystothiazole C, Org. Biomol. Chem., 2014, 12, 8453–8461.

    Supported Projects

    1. National Basic Research Program of China (Grants 2015CB931903 and 2012CB822101)
    2. National Key Research and Development Program of China (2016YFA0203102) 
    3. Strategic Priority Research Program of Chinese Academy of Sciences (Grant XDB14040201, YSW2013A01)
    4. MOST of China (Projects 2012CB822101 and 2012ZX09502001)
    5. National 863 projects(2008AA062502 and 2013AA0652051)
    6. Innovative special funding for drug research (Projects 2012ZX09502001 and 2009ZX09501-011)
    7. National Natural Science Foundation of China (Projects 21672255, 21577154, 21377143, 21372254, 21321004, and 21277166)

    Awards

    2013, Chinese Academy of Sciences outstanding achievement award