干细胞毒理学研究组课题组简介

干细胞毒理学研究组研究队伍

干细胞毒理学研究组承担项目

1. 中国科学院生态环境研究中心 “百人计划”项目（121311ZXPP2014004 ），2014.03-2017.03
2. 中国科学院战略性先导科技专项（B类）（XDB14040300）典型污染物诱导干细胞癌变的机理，2014.06-2019.05
3. 中国科学院“百人计划”A类（29人字[2015]30号），2015.01-2018.12
4. 国家自然科学基金面上项目（21577166），利用多能干细胞研究环境污染物的健康效应及风险评估，2016.01-2019.12
5. 国家自然科学基金面上项目（21577167），新型持久性环境污染物对间充质干细胞自我更新和分化能力的影响机制，2016.01-2019.12

干细胞毒理学研究组近期成果

1. Francesco Faiola,* Nuoya Yin, Xinglei Yao, and Guibin Jiang. The rise of stem cell toxicology. Environmental Science & Technology. 2015, 49(10):5847-5848.*Corresponding author
2. Yao X, Yin, N., Faiola, F*. Stem cell toxicology: a powerful tool to assess pollution effects on human health. National Science Review (accepted)
3. Nuoya Yin, Xinglei Yao, Qunfang Zhou, Francesco Faiola,* Guibin Jiang. Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats. Biochemical and Biophysical Research Communications. 2015, 458(2):405-410.*Corresponding author.
4. Nuoya Yin, Xinglei Yao, Zhanfen Qin, Yuan-Liang Wang, Francesco Faiola*. Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells. Journal of Environmental Sciences. 2015, 36:181-187.*Corresponding author.
5. Junjun Ding, Xin Huang, Ningyi Shao, Hongwei Zhou, Dung-Fang Lee, Francesco Faiola, Miguel Fidalgo, Diana Guallar, Arven Saunders, Pavel V. Shliaha, Hailong Wang, Avinash Waghray, Dmitri Papatsenko, Carlos Sánchez-Priego, Dan Li, Ye Yuan, Ihor R. Lemischka, Li Shen, Kevin Kelley, Haiteng Deng, Xiaohua Shen, Jianlong Wang. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. Cell Stem Cell. 2015, 16(6):653-668.
6. Yael Costa,* Junjun Ding,* Thorold W. Theunissen,* Francesco Faiola,* Timothy A. Hore, Pavel V. Shliaha, Miguel Fidalgo, Arven Saunders, Moyra Lawrence, Sabine Dietmann, Satyabrata Das, Dana N. Levasseur, Zhe Li, Mingjiang Xu, Wolf Reik, José C.R. Silva, and Jianlong Wang. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013, 495(7441):370-374.*These authors contributed equally.
7. Julian A. Gingold, Miguel Fidalgo, Diana Guallar, Zerlina Lau, Zhen Sun, Hongwei Zhou, Francesco Faiola, Xin Huang, Dung-Fang Lee, Avinash Waghray, Christoph Schaniel, Dan P. Felsenfeld, Ihor R. Lemischka, Jianlong Wang. A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming. Molecular Cell. 2014, 56(1):140-152.
8. Miguel Fidalgo, Francesco Faiola, Carlos-Filipe Pereira, Junjun Ding, Arven Saunders, Julian Gingold, Christoph Schaniel, Ihor R. Lemischka, José C. R. Silva, and Jianlong Wang. Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Proceedings of the National Academy of Sciences of the United States of America. 2012, 109(40):16202-16207.
9. Junjun Ding, Huilei Xu,* Francesco Faiola,* Avi Ma'ayan, Jianlong Wang. Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Research. 2012, 22(1):155-167.*These authors contributed equally.
10. Yuan-Liang Wang, Francesco Faiola, Muyu Xu, Songqin Pan, and Ernest Martinez. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. The Journal of Biological Chemistry. 2008, 283(49):33808-33815. (Selected for Faculty of 1000 Biology).
11. Francesco Faiola,* Xiaohui Liu,* Szuying Lo, Songqin Pan, Kangling Zhang, Elena Lymar, Anthony Farina, and Ernest Martinez. Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Molecular and Cellular Biology. 2005, 25(23):10220-10234. *These authors contributed equally.

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