内分泌干扰物与发育毒性研究组课题组简介

内分泌干扰物与发育毒性研究组研究队伍

内分泌干扰物与发育毒性研究组承担项目

1. 国家自然科学基金面上项目《环境雌激素诱导两栖动物雌性化的分子机制研究》（2017.1-2020.12)
2. 国家自然科学基金面上项目《双酚类化合物的甲状腺激素信号通路干扰及相关神经毒性》（2014.1-2017.12）
3. 中国科学院前沿科学重点研究项目《PBDEs对非洲爪蟾的生殖发育毒性及其机制》（2017.1-2021.12）
4. 中国科学院战略性先导科技专项《典型污染物的环境暴露与健康危害机制》子课《甲状腺激素信号介导的化学污染物脑发育毒性研究》（2014.7-2019.7）
5. 国家自然科学基金面上项目《典型污染区得克隆人体内暴露水平、暴露途径和毒性效应研究》（2015.1-2018.12）
6. 国家自然科学基金面上项目《典型污染区哺乳期母乳中卤代有机污染物的变化趋势及控制因素》（2012.1-2015.12）
7. 国家自然科学基金面上基金项目《点源污染中多溴联苯醚的迁移转化规律与来源判别》(2012.1-2015.12)
8. 国家自然科学基金面上项目《基于两栖动物的全氟辛烷磺酸基化合物替代产品的生态毒理学评价》（2011.1-2013.12）
9. 国家自然科学基金面上项目《典型污染区多溴联苯醚的代际转运规律研究》(2009.1-2011.12)
10. 环保公益性行业科研专项项目《基于我国本土生物种的化学品毒性评价方法和管理技术》（2011.1-2013.12）
11. 科技部863计划资源环境领域重大项目《化学品风险评估与风险控制技术》中课题《化学品毒性高通量生物测试与评价技术》之子课题（2012.1-2015.6）

内分泌干扰物与发育毒性研究组近期成果

1. Wu Ping-Fan, Yu Lian-Lian, Li Long, Zhang Yun, Li Xing-Hong*. Maternal transfer of dechloranes and their distribution among tissues in contaminated ducks. Chemosphere 2016, 150: 514-519.
2. Li Yuan-Yuan, Chen Juan, Qin Zhan-Fen*. Determining the optimal developmental stages of Xenopus laevis forinitiating exposures to chemicals for sensitively detecting theirfeminizing effects on gonadal differentiation. Aquatic Toxicol 2016, 179: 134–142.
3. Zhao Ya-Xian, Li Yuan-Yuan, Qin Xiao-Fei, Lou Qin-Qin, Qin Zhan-Fen*. Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site. Environmental Pollution 2016, 218: 1334-1341.
4. Li Yuan-Yuan, Xu Wei, Chen Xiao-Ran, Lou Qin-Qin, Wei Wu-Ji, Qin Zhan-Fen*. Low concentrations of 17β-trenbolone induce female-to-male reversal and mortality in the frog Pelophylax nigromaculatus. Aquatic Toxicol 2015, 58: 230–237.
5. Ren Xiao-Min, Zhang Yin-Feng, Guo Liang-Hong*, Qin Zhan-Fen*, Lv Qi-Yan, Zhang Lian-Ying. Structure-activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor. Arch Toxicol 2015, 89:233–242.
6. Liu Peng-Yan, Chen Xiao-Ran, Zhao Ya-Xian, Li Yuan-Yuan, Qin Xiao-Fei, Qin Zhan-Fen*. Changes of polybrominated diphenyl ether concentrations in ducks with background exposure level and time. Chemosphere 2015, 118: 253–260.
7. Xu Wei, Li Yuan-Yuan, Lou Qin-Qin, Chen Xiao-Ran, Qin Zhan-Fen*, Wei Wu-Ji*. Low concentrations of dihydrotestosterone induce female-to-male sex reversal in the frog Pelophylax nigromaculatus. Environ Toxicol Chem 2015, 34(10): 2370-2377.
8. Zhang Yin-Feng, Li Yuan-Yuan, Qin Zhan-Fen*, Wang Hui-Li*, Li Jian-Zhong. A screening assay for thyroid hormone (TH) signaling disruption based on TH-response gene expression analysis in the frog Pelophylax nigromaculatus. J Environ Sci 2015, 34: 143-154.
9. Quan-Xia Lv, Wenyue Wang, Xing-Hong Li* et al., Polychlorinated biphenyls and polybrominated biphenyl ethers in adipose tissue and matched serum from an E-waste recycling area (Wenling, China). Environmental Pollution 2015,199, 219-226.
10. Dong Yuan, Fu Shan*, Zhang Yong-Fei, Nie Hai-Feng, Li Zheng. Polybrominated diphenyl ethers in atmosphere from three different typical industrial areas in Beijing, China. Chemosphere 2015,123:33-42.
11. Zhang Yin-Feng, Xu Wei, Lou Qin-Qin, Li Yuan-Yuan, Zhao Ya-Xian, Wei Wu-Ji, Qin Zhan-Fen*, Wang Hui-Li*, Li Jian-Zhong. Tetrabromobisphenol A disrupts vertebrate development via thyroid hormone signaling pathway in a developmental stage-dependent Manner. Environ Sci Technol 2014, 48(14):8227–8234.
12. Cao Shan, Wei Xu, Lou Qin-Qin, Zhang Yin-Feng, Zhao Ya-Xian, Wei Wu-Ji*, Qin Zhan-Fen*. Environmental (anti-)androgenic chemicals affect germinal vesicle breakdown (GVBD) of Xenopus laevis oocytes in vitro. Toxicol in Vitro 2014, 28(3): 426–431.
13. Lou Qin-Qin, Cao Shan, Xu Wei, Zhang Yin-Feng, Qin Zhan-Fen*, Wei Wu-Ji. Molecular characterization and mRNA expression of ribosomal protein L8 in Rana nigromaculata during development and under exposure to hormones. J Environ Sci 2014，26：2331-2339.
14. Lou Qin-Qin, Zhang Yin-Feng, Ren Dong-Kai, Xu Hai-Ming, Zhao Ya-Xian, Qin Zhan-Fen *, Wei Wu-Ji. Molecular characterization and developmental expression patterns of thyroid hormone receptors (TRs) and their responsiveness to TR agonist and antagonist in Rana nigromaculata. J Environ Sci 2014, 26: 2084 – 2094.
15. Ben Yu-Jie, Li Xing-Hong * et al., Placental transfer of Dechlorane Plus in mother–infant pairs in an e-waste recycling area (Wenling, China). Environ Sci Technol 2014, 48, 5187-5193;
16. Li Long, Li Xing-Hong *, et al, Bioavailability and tissue distribution of Dechloranes in wild frog (Rana limnocharis) from an e-waste recycling area in Southeast China. J Environ Sci. 2014, 26, 636-642;
17. Nie Hai-Feng, Fu Shan*, Dong Yuan, Yang Z. Polychlorinated biphenyls in respirable particulate matter from different industrial areas in northern China. Chemosphere 2014, 114:210-218.
18. Ben Yu-Jie, Li Xing-Hong* , et al., Dechlorane Plus and its dechlorinated analogs from an e-waste recycling center in maternal serum and breast milk of women in Wenling, China. Environ Poll 2013, 173: 176-181.
19. Zhao Ya-Xian, Ruan Xian-Li, Li Yan, Yan Min-Chan, Qin Zhan-Fen*. Polybrominated diphenyl ethers (PBDEs) in aborted human fetuses and placental transfer during the first trimester of pregnancy. Environ Sci Technol 2013, 47(11):5939-5946.
20. Lou Qin-Qin, Zhang Yin-Feng, Zhou Zhen, Shi Ya-Li, Ge Ya-Nan, Ren Dong-Kai, H Xu ai-Ming, Zhao Ya-Xian, Wei Wu-Ji *, Qin Zhan-Fen *. Effects of perfluorooctanesulfonate and perfluorobutanesulfonate on the growth and sexual development of Xenopus laevis. Ecotoxicology 2013, 22:1133-1144.
21. Ben Yu-Jie, Li Xing-Hong* , et al. Dechlorane Plus and its dechlorinated analogs from an e-waste recycling center in maternal serum and breast milk of women in Wenling, China. Environ Poll 2013, 173: 176-181.
22. Liu Peng-Yan, Zhao Ya-Xian, Zhu Yi-Yang, Qin Zhan-Fen*, Xian-Li Ruan, Yong-Chuan Zhang, Bao-Jun Chen, Yan Li, Shi-Shuai Yan, Xiao-Fei Qin, Shan Fu. Determination of polybrominated diphenyl ethers in human semen. Environ Int 2012, 42:132–137.
23. Qin Xiao-Fei, Qin Zhan-Fen*, Li Yan, Zhao Ya-Xian, Xia Xi-Juan, Yan Shi-Shuai, Tian Mi, Yang Zhong-Zhi, Fu Shan, Xu Xiao-Bai, Yang Yong-Jian. Polybrominated diphenyl ethers in chickens and eggs from an e-waste recycling area in Southeast China. J Environ Sci 2011, 23(1): 133–138.
24. Zhang Xiao-You, Ruan Xian-Li, Yan Min-Chan, Zhao Ya-Xian, Wei Wu-Ji *, Qin Zhan-Fen*, Yang Yong-Jian, Xu Hai-Ming, Li Yan. Polybrominated diphenyl ether (PBDE) in blood from children (9-12 Years of Age) in Taizhou country, China. J Environ Sci 2011, 23(7): 1199–1204.
25. Liu Peng-Yan, Du Guo-Dong, Zhao Ya-Xian, Mu Yun-Song, Zhang Ai-Qian, Qin Zhan-Fen*, Zhang Xiao-You, Yan Shi-Shuai, Li Yan, Wei Rong-Guo, Qin Xiao-Fei, Yang Yong-Jian. Bioaccumulation, maternal transfer and elimination of polybrominateddiphenyl ethers in wild frogs. Chemosphere 2011, 84(7): 972–978.

内分泌干扰物与发育毒性研究组获奖情况

1. “典型化学污染物环境过程机制及生态效应”获2005年度国家自然科学二等奖
2. “复杂环境介质中痕量污染物和手性污染物分析的新方法及其应用研究” 获2006年度中国分析测试协会科学技术二等奖
3. 2013年度中国科学院杰出科技成就奖（集体奖）。

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