研究队伍

简历:
博士,研究员,博士生导师,中科院“百人计划”入选者。
Francesco Faiola研究员于2006年获美国加州大学河滨分校博士学位。2006-2014年先后在美国加州大学河滨分校和美国西奈山伊坎医学院完成博士后学习和深造,在干细胞生物学领域具备深厚的研究背景,相关研究成果发表于Nature、PNAS、Molecular Cells、Cell Research等高水平学术期刊。2014年入选中科院“百人计划”,是生态环境研究中心引进的第一位外籍研究员。主要从事环境污染物的干细胞毒理学研究,在生态环境研究中心建立了国际上第一个污染物干细胞毒理学实验室。
社会任职:
承担科研项目:
- 中国科学院生态环境研究中心 “百人计划”项目(121311ZXPP2014004 ),2014.03-2017.03
- 中国科学院战略性先导科技专项(B类)(XDB14040300)典型污染物诱导干细胞癌变的机理,2014.06-2019.05
- 中国科学院“百人计划”A类(29人字[2015]30号),2015.01-2018.12
- 国家自然科学基金面上项目(21577166),利用多能干细胞研究环境污染物的健康效应及风险评估,2016.01-2019.12
代表论著:
- Faiola F*, Yin N, Yao X, Jiang G. The rise of stem cell toxicology. Environ Sci Technol. 2015 May 19;49(10):5847-8.
- Yin N, Yao X, Zhou Q, Faiola F*, Jiang G. Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats. Biochem Biophys Res Commun. 2015 Mar 6;458(2):405-10.
- Yin N, Yao X, Qin Z, Wang YL, Faiola F*. Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells. J Environ Sci (China). 2015 Oct 1;36:181-7.
- Costa, Y.*, Ding, J.*, Theunissen, T.W.*, Faiola, F.*, Hore, T.A., Shliaha, P.V., Fidalgo, M., Saunders, A., Lawrance, M., Dietmann, S., Das, S., Levasseur, D.N., Li, Z., Xu, M., Reik, W., Silva, J.C.R. & Wang, J. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013 Mar 21;495(7441):370-4. *These authors contributed equally.
- Fidalgo M, Faiola F, Pereira CF, Ding J, Saunders A, Gingold J, Schaniel C, Lemischka IR, Silva JC, Wang J. Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Proc Natl Acad Sci U.S.A. 2012 Oct 2;109(40):16202-7.
- Ding, J., Xu, H.*, Faiola, F.*, Ma’ayan, A. & Wang, J. Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Res. 2012 Jan;22(1):155-67. *These authors contributed equally.
- Saunders A, Faiola F, Wang J. Concise review: pursuing self-renewal and pluripotency with the stem cell factor Nanog. Stem Cells. 2013 Jul;31(7):1227-36.
- Wang YL, Faiola F, Martinez E. Purification of multiprotein histone acetyltransferase complexes. Methods Mol Biol. 2012;809:427-43.
- Faiola F, Wu YT, Pan S, Zhang K, Farina A, Martinez E. Max is acetylated by p300 at several nuclear localization residues. Biochem J. 2007 May 1;403(3):397-407.
- Faiola F, Liu X, Lo S, Pan S, Zhang K, Lymar E, Farina A, Martinez E. Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol. 2005 Dec;25(23):10220-34.